Ernesto Fedele Selected Research

GEBR-7b

11/2016

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment.

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Ernesto Fedele Research Topics

Disease

11	Alzheimer Disease (Alzheimer's Disease) 04/2022 - 02/2013
8	Parkinson Disease (Parkinson's Disease) 04/2022 - 03/2005
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 04/2022 - 02/2015
2	Disease Progression 09/2019 - 06/2009
2	Vomiting 12/2017 - 11/2016
2	Dyskinesias (Dyskinesia) 05/2017 - 06/2009
1	Huntington Disease (Huntington's Disease) 04/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2022
1	Multiple Sclerosis 04/2022
1	Mental Disorders (Mental Disorder) 10/2019
1	Cognitive Dysfunction 01/2017
1	Intellectual Disability (Idiocy) 01/2017
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/2010
1	Parkinsonian Disorders (Parkinsonism) 09/2009
1	Nervous System Diseases (Neurological Disorders) 08/2008

Drug/Important Bio-Agent (IBA)

4	Amyloid (Amyloid Fibrils)IBA 01/2018 - 12/2015
3	Glutamic Acid (Glutamate)FDA Link 09/2019 - 10/2010
3	Peptides (Polypeptides)IBA 01/2017 - 12/2015
2	Protein Isoforms (Isoforms)IBA 12/2017 - 10/2015
2	Dopamine (Intropin)FDA LinkGeneric 05/2017 - 06/2009
2	Amyloid beta-PeptidesIBA 01/2017 - 02/2013
1	MicroRNAs (MicroRNA)IBA 04/2022
1	Biomarkers (Surrogate Marker)IBA 04/2022
1	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 01/2021
1	tau Proteins (tau Protein)IBA 01/2021
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 10/2019
1	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 09/2019
1	Proteins (Proteins, Gene)FDA Link 01/2019
1	Pharmaceutical PreparationsIBA 12/2017
1	Homovanillic AcidIBA 05/2017
1	GDP dissociation inhibitor 1IBA 01/2017
1	GEBR-7bIBA 11/2016
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 11/2016
1	EnzymesIBA 10/2015
1	amphiphysinIBA 02/2015
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 02/2015
1	gamma-Aminobutyric Acid (GABA)IBA 02/2015
1	Phosphotransferases (Kinase)IBA 01/2014
1	Leucine (L-Leucine)FDA Link 01/2014
1	D-Aspartic Acid (D Aspartate)IBA 10/2010
1	PesticidesIBA 08/2008
1	RotenoneIBA 08/2008

Therapy/Procedure

4	Deep Brain Stimulation 01/2011 - 03/2005
2	Therapeutics 04/2022 - 01/2021